Protein name:
SPARC ;
Alternative:
Osteonectin (ON) ;Basement-membrane protein 40 (BM-40) ;Secreted protein acidic and rich in cysteine ;
Organism:
Human (Homo sapiens).
General Annotation
Function:
Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity.
Subcellular Location:
Secreted
extracellular space
extracellular matrix
basement membrane
In or around the basement membrane.
Protein Attributes:
50:
MRAWIFFLLC | LAGRALAAPQ | QEALPDETEV | VEETVAEVTE | VSVGANPVQV |
100:
EVGEFDDGAE | ETEEEVVAEN | PCQNHHCKHG | KVCELDENNT | PMCVCQDPTS |
150:
CPAPIGEFEK | VCSNDNKTFD | SSCHFFATKC | TLEGTKKGHK | LHLDYIGPCK |
200:
YIPPCLDSEL | TEFPLRMRDW | LKNVLVTLYE | RDEDNNLLTE | KQKLRVKKIH |
250:
ENEKRLEAGD | HPVELLARDF | EKNYNMYIFP | VHWQFGQLDQ | HPIDGYLSHT |
300:
ELAPLRAPLI | PMEHCTTRFF | ETCDLDNDKY | IALDEWAGCF | GIKQKDIDKD |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Rat
Bovine
Pig
Chicken
Rabbit
ELISA Kit for Human SPARC
ELISA Kit for Human SPARC
ELISA Kit for Human SPARC
ELISA Kit for Human SPARC
ELISA Kit for Human SPARC
ELISA Kit for Human SPARC
ELISA Kit for Human SPARC
Polyclonal Antibody for Human SPARC
Polyclonal Antibody for Human SPARC
Polyclonal Antibody for Human SPARC
Polyclonal Antibody for Human SPARC
Polyclonal Antibody for Human SPARC
Polyclonal Antibody for Human SPARC
Polyclonal Antibody for Human SPARC
Monoclonal Antibody for Human SPARC
Monoclonal Antibody for Human SPARC
Monoclonal Antibody for Human SPARC
Monoclonal Antibody for Human SPARC
Monoclonal Antibody for Human SPARC
Monoclonal Antibody for Human SPARC
Monoclonal Antibody for Human SPARC
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];PARTIAL PROTEIN SEQUENCE
tissue :
Placenta .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA]
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
6.
Mural R.J.
,
Istrail S.
,
Sutton G.G.
,
Florea L.
,
Halpern A.L.
,
Mobarry C.M.
,
Lippert R.
,
Walenz B.
,
Shatkay H.
,
Dew I.
,
Miller J.R.
,
Flanigan M.J.
,
Edwards N.J.
,
Bolanos R.
,
Fasulo D.
,
Halldorsson B.V.
,
Hannenhalli S.
,
Turner R.
,
Yooseph S.
,
Lu F.
,
Nusskern D.R.
,
Shue B.C.
,
Zheng X.H.
,
Zhong F.
,
Delcher A.L.
,
Huson D.H.
,
Kravitz S.A.
,
Mouchard L.
,
Reinert K.
,
Remington K.A.
,
Clark A.G.
,
Waterman M.S.
,
Eichler E.E.
,
Adams M.D.
,
Hunkapiller M.W.
,
Myers E.W.
,
Venter J.C.
more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Muscle .
tissue :
PNS .
tissue :
Skin .
8.
"The full-ORF clone resource of the German cDNA consortium."
Bechtel S.
,
Rosenfelder H.
,
Duda A.
,
Schmidt C.P.
,
Ernst U.
,
Wellenreuther R.
,
Mehrle A.
,
Schuster C.
,
Bahr A.
,
Bloecker H.
,
Heubner D.
,
Hoerlein A.
,
Michel G.
,
Wedler H.
,
Koehrer K.
,
Ottenwaelder B.
,
Poustka A.
,
Wiemann S.
,
Schupp I.
more...
BMC Genomics8:399-399(2007)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-154
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 18-53;CHARACTERIZATION
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 18-41;CHARACTERIZATION;SUBCELLULAR LOCATION
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SUBCELLULAR LOCATION
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SUBCELLULAR LOCATION
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SUBCELLULAR LOCATION
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 153-303
15.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (3.1 ANGSTROMS) OF 71-303 IN COMPLEX WITH CALCIUM IONS;GLYCOSYLATION AT ASN-116;DISULFIDE BONDS
16.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 71-303 IN COMPLEX WITH CALCIUM IONS;GLYCOSYLATION AT ASN-116;INTERACTION WITH COLLAGEN;MUTAGENESIS OF ARG-166; ASN-173; LEU-259; MET-262 AND GLU-263